Stress granule formation via ATP depletion-triggered phase separation

Stress granule formation via ATP depletion-triggered phase separation

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Stress granules (SG) are droplets of proteins and RNA that form in the cell cytoplasm during stress conditions.We consider minimal models read more of stress granule formation based on the mechanism of phase separation regulated by ATP-driven chemical reactions.Motivated by experimental observations, we identify a minimal model of SG formation triggered mpu63zm/a by ATP depletion.

Our analysis indicates that ATP is continuously hydrolysed to deter SG formation under normal conditions, and we provide specific predictions that can be tested experimentally.